Schedule and Speaker List

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Morning Session: Hierarchical modelling (chaired by Jan Brugård, Hiroaki Kitano),
Room: Berzelius-salen

09.00-09.15 Welcome registration

09.15-09.30 Gunnar Cedersund*, Welcome, presentation of workshop

09.30-10.30 Mikael Benson* (MD), IKE, Linköping, UPDATED TIME
                       Integrated clinical, genomic, network and functional studies to find diagnostic markers for personalized medication.

10.30-11.00 Coffee

11.00-11.20 Peter Fritzson*, IDA, Linköping,
                       Introduction to Modelica modeling and the OpenModelica and MathModelica tools

11.20-11.40 Elin Nyman*, IKE, Linköping,
                       Multi-level modeling of type 2 diabetes

11.40-12.00 Matts Karlsson*, IEI, Linköping,
                       Hierarchical modeling of heart bio-mechanics

12.00-12.20 Marek Mateják*, Pavol Privitzer*, Jiří Kofránek (I), Creative Connections, Czech Republic.
                       HumMod - a large hierarchical model of integrative human physiology.

12.30-14.00 Lunch

Afternoon Session: Decision-support and clinical practice (chaired by José Pena, Mikael Benson)
Room: IMT1

14.00-15.00 Hiroaki Kitano*, Tokyo/Linköping, via Skype, UPDATED TIME
                       Systems biology and its application to drug discovery

15.00-15.30 Dirk Repsilber*, Leibniz, Germany.
                       Screening for molecular signatures in heterogeneous tissue and in pooled samples

15.30-16.00 Coffee

16.00-16.30 Ljijana Majnarić*, Croatia
                       Possibilities of a systems biology approach in managing simple, clinical parameters

16.30-17.00 Peter Lucas* (MD), Radboud University, The Netherlands
                       Bayesian Network Modelling for Clinical Decision Making in Liver Disease

17.00-17.30 Agnieszka Onisko*, Pittsburgh, USA, via Skype
                       Bayesian Modelling for Clinical Decision Support when Screening for Cervical Cancer.

17.30-18.00 Discussion

20.00 Dinner


Morning Session Diabetes (chaired by Peter Strålfors, Gunnar Cedersund)
Room: IMT1

09.00-09.15 Gunnar Cedersund*, Introduction to day 2

09.15-09.45 Peter Strålfors*, IKE, Linköping
                       Integration of experiments and mathematical modeling to adipocyte insulin signaling and whole-body glucose homeostasis

09.45-10.15 Matthias König*/Hergo Holzhütter, Berlin, Germany, via Skype
                       A mathematical model and module for liver metabolism

10.15-10.30 Discussion

10.30-11.00 Coffee

11.00-11.30 Folke Sjöberg*, MD, IKE, Linköping
                      Microdialysis to investigate metabolic disorders including in critical care

11.30-12.00 Maria Kjelsson*/Mats Karlsson, Uppsala, Sweden
                       Pharmacokinetic and pharmacodynamic modelling of type 2 diabetes: clinical and pharmaceutical perspectives

12.00-12.30 Morten Gram Pedersen*, University of Padua
                       Multiscale modeling of insulin secretion

12.30-14.00 Lunch

14.00-14.20 Fredrik Nyström*, MD, IMH, Linköping
                       Clinical studies on diabetes and cardiovascular complications at the Linköping University Hospital

14.20-14.40 Ferdinand Stückler*, Munich, Germany,
                       Analysis and modeling of metabolomics data in human cohort and challenging studies

14.40-15.00 Martin Adiels*/Jan Borén (MD), Gothenburg,
                       Measuring lipid metabolism in vivo: Heterogeneity of hypertriglyceridaemia

15.00-15.30 Discussion: possible joint future major clinical studies?

15.30-16.00 Coffee

Afternoon Session: Heart including atherosclerosis (chaired by Toste Länne, Hiroaki Kitano)
Room: IMT1

16.00-16.20 Hiroaki Kitano*, Tokyo/Linköping
                       Overview of HD-physiology network

16.20-16.40 Alfredo Hernandez*, INSERM, Rennes, France
                       Overview of multi-formalism modeling of the cardiovascular system : applications to personalized heart failure therapy

16.40-17.00 Fredrik Elinder*, IKE, Linköping
                       Electrophysiological cell biology and modeling of the heart

17.00-17.20 Karin Lundengård*/Jordi Altimiras*, IFM, Linköping
                       Beta-receptor de-sensitization understood using mathematical modeling

17.20-17.40 Toste Länne*(MD, IMH), Linköping,
                       Modelling and clinical studies of atherosclerosis

17.40-18.15 Discussion: Towards a multi-level model for type 2 diabetes, and its cardiovascular complications?

20 Dinner


Morning Session: Liver diseases (chaired by Mikael Forsgren, Olof Dahlqvist Leinhard)
Room: Wrannesalen CMIV


09.00-09.15 Olof Dahlqvist Leinhard*, CMIV, Linköping, "Introduction to Day 3"

09.15-10.00 Adriano Henney*, Germany
                       The Virtual Liver network

10.00-10.15 Discussion

10.15-10.45 Coffee)

10.45-11.05 Olof Dahlqvist Leinhard*, CMIV, Linköping
                       Non-Invasive Liver Biopsy (NILB) I

11.05-11.25 Bengt Norén* (MD), CMIV, UHL, Linköping
                       Non-Invasive Liver Biopsy (NILB) II

11.25-11.45 Mikael Forsgren*, CMIV, UHL, Linköping
                       Towards deterministic and Bayesian based models as diagnostic tools

11.45-12.00 Discussion

12.00-13.30 Lunch

13.30-14.15 Jose Ulloa*, AstraZeneca, Stockport, UK
                       Evaluation of DCEMRI as a Biomarker of Hepatic Transporters Interactions

14.15-14.30 Discussion

14.30-15.00 Marek J Druzdzel*, Pittsburgh, USA, via Skype
                       Bayesian modeling for clinical decision support when diagnosing diffuse liver disease

15.00-16.00 Coffee and Discussion