Christian Simonsson

Adiponectin, which is a hormone released by mature adipocyte has been shown to have an important role in the development of type-2 diabetes. However, the precise underlying mechanisms for the production and release of such hormones in adipocytes are not fully understood. Therefore, an ongoing project in the ISB group has been to use mathematical modeling to describe the exocytosis of white adipocytes to predict adiponectin secretion, making it possible to quantify the exocytosis and endocytosis rates. An article on the subject was recently published by William Lövfors et al and in my project I will make use of the model presented in this article. The goal is to extend the model to also describe the experimental data for adiponectin secretion induced through the activation of beta-adrenergic signaling pathways upon extracellular adrenalin stimulation. Hopefully this might contribute to creating a more complete framework for understanding the regulation of this important metabolic hormone.