Elin Nyman

Type 2 diabetes is a systems disease, caused by a malfunction in a complex interplay of hormones and metabolites such as insulin, glucose, and fatty acids. To handle this complexity, a multi-level systems pharmacology approach is necessary. During my PhD, I used an integrated experimental/theoretical approach to examine mechanistic hypotheses, and provide a first systems-level explanation to the origin of insulin resistance in human fat cells [1-5]. I finished my PhD (Insulin signaling dynamics in human adipocytes) in March 2013 supervised by Peter Strålfors and Gunnar Cedersund (Linköping University).

I am currently doing a postdoc project in collaboration between Gunnar Cedersund et al (Linköping University) and Peter Gennemark et al (Modeling and Simulation, AstraZeneca). In this project, I am continuing to use the experimental/modeling approach to expand the models developed in my PhD beyond insulin and glucose regulations, to reveal the contribution of fatty acids and lipolysis to the progression of type 2 diabetes. This work is done in collaboration also with Natal van Riel et al (Eindhoven University of Technology).

Other projects I have been involved in concerns modeling beta-cell function in diabetes treatments [6] in collaboration with Robert Palmér (Wolfram MathCore), and dose-response relationships in beta-adrenergic signaling in cardiac tissue [7] in collaboration with Jordi Altimiras (Linköping University).

Publications

  1. Nyman, E., Rohini Rajan, M., Fagerholm, S., Brannmark, C., Cedersund, G. & Stralfors, P. (2014)
    A Single Mechanism can Explain Network-Wide Insulin Resistance in Adipocytes from Obese Patients with Type 2 Diabetes
    J Biol Chem. 2014 289 33215-30

  2. Brännmark, C., Nyman, E., Fagerholm, S., Bergenholm, L., Ekstrand, E. M., Cedersund, G. & Strålfors, P. (2013)
    Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes
    J Biol Chem. 288, 9867-80.

  3. Nyman, E., Brännmark, C., Palmér, R., Brugård, J., Nyström, F. H., Strålfors, P. & Cedersund, G. (2011)
    A hierarchical whole-body modeling approach elucidates the link between in Vitro insulin signaling and in Vivo glucose homeostasis
    J Biol Chem. 286, 26028-41.

  4. Nyman, E., Cedersund, G. & Stralfors, P. (2012)
    Insulin signaling - mathematical modeling comes of age
    Trends Endocrinol Metab. 23, 107-15.

  5. Nyman, E., Fagerholm, S., Jullesson, D., Stralfors, P. & Cedersund, G. (2012)
    Mechanistic explanations for counter-intuitive phosphorylation dynamics of the insulin receptor and insulin receptor substrate-1 in response to insulin in murine adipocytes
    FEBS J. 279, 987-99.

  6. Palmer, R., Nyman, E., Penney, M., Marley, A., Cedersund, G. & Agoram, B. (2014)
    Effects of IL-1beta-Blocking Therapies in Type 2 Diabetes Mellitus: A Quantitative Systems Pharmacology Modeling Approach to Explore Underlying Mechanisms
    CPT Pharmacometrics Syst Pharmacol. 3, e118.

  7. Nyman, E., Lindgren I., Lövfors, W., Lundengård, K., Cervin, I., Sjöström, T.A., Altimiras, J. & Cedersund, G. (2015)
    Mathematical modeling improves EC50 estimations from classical dose-response curves
    FEBS J. 2015 Jan 13. doi: 10.1111/febs.13194.