Kajsa Tunedal

In the bachelor project we created a new liver model describing fatty acid conversion. Now, I will continue the work of the previous students Valentin Kindesjö, Thirza Poot and Johanna Fridberger to put together a model that describes fatty acid and glucose fluxes during the day and how it’s affected by different factors such as insulin and cortisol. My main focus will be at the fatty acid part and I will continue to work on my liver model as well as Valentin’s adipose- and cortisol module, which all will be parts of the bigger model.

I will also look at newly published data on body fat distribution in connection to diseases such as type 2 diabetes and coronary heart disease. A future goal is to connect the data to our models and being able to describe how the fatty acid homeostasis is affected by stress factors such as disturbed cortisol levels and why this in some cases cause diseases. By doing this, we are getting closer to simulating clinical studies and predicting diseases.