Karin Hedin

The focus of the research project that I am a part of is to better understand how metabolism is altered in patients with diseases that are coupled to metabolic abnormalities such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2D). My work as a research engineer and experimentalist at the Department of Biomedical Engineering (IMT) primarily involves doing ex vivo experiments on human liver and adipocyte tissue, which allows for molecular analysis of metabolic fluxes in these samples to be carried out. The data generated from these analyses is then used by engineers at IMT to create digital twins of these organ types. The aim is that these models will be able to predict different disease outcomes in patients suffering from NAFLD and T2D and consequently provide further insight into the enigma that is the metabolic syndrome.